DECIPHERING TRANSCRIPTION FACTORS AND THEIR CORRESPONDING REGULATORY ELEMENTS DURING INHIBITORY INTERNEURON DIFFERENTIATION USING DEEP NEURAL NETWORKS

Deciphering transcription factors and their corresponding regulatory elements during inhibitory interneuron differentiation using deep neural networks

During neurogenesis, the generation and differentiation of neuronal progenitors into inhibitory gamma-aminobutyric acid-containing interneurons is dependent on the combinatorial activity of transcription factors (TFs) and their corresponding regulatory elements (REs).However, the roles of neuronal TFs and their target REs in inhibitory interneuron

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Branch-Well-Structured Transition Systems and Extensions

We propose a relaxation Knitwear to the definition of well-structured transition systems (WSTS) while retaining the decidability of boundedness and non-termination.In this class, the well-quasi-ordered (wqo) condition is relaxed such that it is applicable only between states that are reachable one from another.Furthermore, the monotony condition is

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Biochemical and Transcriptomic Analysis Reveals Low Temperature-Driven Oxidative Stress in Pupal Apis mellifera Neural System

Exposure to low temperatures during honeybee development has been shown to impede brain development and affect cognitive function in adult bees.On the other hand, neuronal damage due to oxidative stress has been reported in many cases.Hence, biochemical parameters related to oxidative stress in honeybee pupae brain were determined.The levels of GSH

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